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Computer aided detection system using soft tissue technique using x-ray image

Computer aided detection system using soft tissue technique using x-ray image

Dr. R. Suresh Babu, Mr.R.Kishore

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Department of ECE”,

Kamaraj College of Engineering and Technology”, and


Lung Cancer is a pathological threat throughout world. Such threat needs to be detected early. So, it depends upon nodule size. Analyzing x-ray images is a nontrivial task and decisions from investigation of these kinds require specialized knowledge. Computer Aided Detection system (CADs) can help radiologist for reliable decisions. Unfortunately, CADs missed thirty percent nodules. So”,we recently introduce soft tissue technique. x-ray images are downloaded from JSRT database. This paper proposes soft tissue technique. Specifically, CADs system using soft tissue technique have developed from x-ray image. Support Vector Machine (SVM) layers have been used for the decision-making stage after extracting features.

Keywords: lung cancer, computer aided detection, x-ray image, soft tissue technique, JSRT Database

I. Introduction

Every year (2009), American Cancer Society announced overall lung cancer 14% curable rate having stages combined (early, middle & advanced stages) [1]. Lung cancer, starting stage, improve curable rate by 50%. In recent days, it is a challenging task when rib and clavicle feature are being overlapped with lung nodule.

A sensitive technique was needed [2]. X-ray image is being preferred because it’s cost-effective, routinely accessible plus dose-effective tool [3]. Radiologists missed 30% nodules in x ray image and that, 82-95% among missed nodules partly obscured by overlying bones such as ribs plus clavicles [4][5].

A major challenge for current CAD system is detect nodules overlapping ribs, rib crossings, plus clavicles. This leads lowering sensitivity. Nicholas J. Novak [6] detect small lung cancers using dual energy subtraction radiography method. This would increase efficiency but the hospital requires specialized equipments. Matsumoto, proposed CAD system at a FP rate equals 11 per image, even though it had 80% sensitivity. But, accuracy was not improved [7].

In this work, we need to develop a CADs model using soft tissue technique to improve sensitivity with the same FP rate and simultaneously reduces FP rate by reducing improved sensitivity. Hence, accuracy need to be improved while making a good decision.

II. Materials and Methods

A. Database of X-Ray Image

154 nodules images plus 93 normal images downloaded from publicly available JSRT (Japanese Society of Radiological Technology) database [8]. nodule size ranged

15 to 24 mm. The images were digitized to yield 12-bit chest x rays (CXRs) with a resolution contains 2048 × 2048 pixels. Pixel was 0.175 × 0.175 milli metres. Missed nodules were divided into five categories based on subtlety rating. Five categories are extremely subtle, very subtle, subtle, relatively obvious and obvious.

B. CAD System

X-ray images obtained by using single exposure technique having two detectors seperated by copper filter [3] [6]. The original image’s dimension are 1760 x 1760.The images are linearly sub-sampled to 512 x 512 dimension. This was done to facilitate experimentation as it allows for a considerable decrease in computation time. System performed lung segmentation for extracting lung boundary [9]. The various segmentation methods are rule based methods, pixel based methods, hybrid methods and deformable model based methods. After lung fields segmented, background trend correction method applied to segmented lung field. A second order bivariate polynomial function was fitted to each of the left and right lung fields where F(u”,v)= au2+bv2+cuv+du+ev+f represent polynomial function having a, b, c, d, e, f as co-efficient calculated for each parameter. Subsequently, the fitted functions for the left and right lung fields were subtracted from the original image a(u”,v). In this approach, a background trend in the lung fields as a low frequency surface was removed [10].

The pre-processed image in CAD system was applied to different types of gray level morphological open operation to form a nodule enhanced image and a nodule enhanced image is modified in the nodule likelihood map [11]. It results in nodule candidate detection based on local peaks in the map. This nodule candidate is very important to find the lung to locate boundary. Peaks within the nodule candidate region in the nodule enhanced image is used to

initialize candidate segmentation using watershed technique. With the watershed technique [12], the nodule candidate region was divided into several gray levels. The advantage of this technique is able to produce good segmentation results and it would be more useful to focus on nodule candidates. Finally, gray level features were extracted from nodule candidates.

The name of the gray level features are contrast, correlation, energy, homogeneity and entropy. Based on the extraction of gray level features, feature selection method based on genetic algorithm [13] is used to determine the optimal size of a feature set automatically. The optimal size of a feature set is given as input to support vector machine for classifying nodule candidates [14]. A major issue for the detection of lung cancer in CAD system is to detect lung nodules overlapping ribs and clavicles in pre-processed image. Due to this issue, radiologist miss 30% nodules. So, the sensitivity of this system is also reduced. In order to improve the sensitivity, we create a soft tissue image from x-ray for the detection of nodule candidate.

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C. Creation of soft tissue image

A soft tissue technique [6] [15] [23] [24] created using x ray image. It was used in rib and clavicle suppression form. Fig 2 shows soft tissue image creation from x-ray. MTANN is non linear filter which needs to be trained using x ray image and corresponding teaching image. Here we consider the corresponding teaching image is bone.

fb(u”,v) =NN (au”,v) ———————————————-(1)

Where au”,v = {g(u-i”,v-j) |i”,j є Rs } is a input vector to MTANN which is a subregion and fb(u”,v) is an estimate for a teaching value. The MTANN is trained by using subregions together with every corresponding teaching single pixels. The training set of pairs of a sub region and a teaching pixel is represented by

{a(u-i”,v-j), T(i”,j)| u”,v є RT }

= { (a1 “,T1) (a2″,T2) (aN”,TN) }————————–(2)

Where T(i”,j) is a teaching image, RT is a training region corresponds to collection of sub region centers and N is number of pixels.. For a single MTANN, suppression of ribs containing various frequencies was difficult due to limited capability. In order to overcome this issue multiresolution decomposition/composition techniques were applied.

First”,a lower resolution image GL(u”,v) was obtained from an original higher resolution image [15] GH(2u”,2v) by performing downsampling with averaging i.e., four pixels in the original image are replaced by a mean value of four pixels represented by

GL(u”,v) = (1/4) ∑ GH(2u, 2v)—————————(3)

u”,v є R22

[image: image1.png]

Fig 1 CAD system

[image: image2.png]

Fig 2 soft tissue image creation from x-ray

where R22 is a 2 x 2 pixel region. The lower resolution image is enlarged by upsampling with pixel substitution i.e., a pixel of lower resolution image is replaced by four pixels with the same pixel value, as follows:


Then, we subtract enlarged lower resolution image from the higher resolution image to get high resolution difference image, represented by

DH(u”,v) = GH(u”,v) – GU(u”,v) ——————————–(5)

These procedures are performed again and again producing

further lower resolution images. Thus, multiresolution images with various frequencies are obtained by the use of multiresolution decomposition technique. An important property of this technique is the same high resolution image GH(u”,v) that can be obtained as follows:

GH(u”,v)=GU(u”,v)+DH(u”,v) ————————————(6)

Therefore, we can choose multiresolution images for processing independently instead of processing original high resolution images directly. After training with input x ray image and the dual energy bone image, the multiresolution MTANN is able to produce bone image that are expected to be similar to the teaching bone image.

The bone image fb(u”,v) produced by the trained MTANN with the lung masking image n(u”,v) and weighting parameter wc is subtracted from the sub region of original x ray image g(u”,v) to create a soft tissue image.

f(u”,v)= g(u”,v) – wc x fb(u”,v) x n(u”,v)————————(7)

where f(u”,v) denotes the soft tissue image with different

types of rib contrast by the use of weighting parameter wc.

D. CAD System using soft tissue technique

The CAD system segments the lung for identifying sub region, create the soft tissue technique to detect nodule candidate on soft tissue image, segments the nodule candidates on soft tissue image which proceed with feature extraction and classification for the detection of lung nodules. Segmentation of nodule candidates is done by the use of clustering watershed method. Fig 3 shows the development of a proposed CAD system with soft tissue technique for the detection of subtle nodules to reduce rib-induced false positives. Peaks within the nodule candidate region in the nodule enhanced image were obtained and used to initialize the clustering watershed method [12].

With the clustering watershed method, the nodule candidate regions were divided into several catchment basins. Each minimum point were surrounded by a catchment basin associated with it; there were one or more peaks, each of which were surrounded by a cluster of connected pixels that consituted a catchment basin.

The features of the nodules were suppressed in soft tissue

image. Detection of nodule candidate on soft tissue image

may be misclassified as non-nodules. So, the segmentation step is being repeated on soft tissue and x ray image. Sixty morphologic and gray level based features were extracted from each candidate from both x ray and soft tissue image and it is given as input to feature selection method based on

genetic algorithm [13]. A non linear SVM with a Gaussian kernel was employed for the classification of nodule candidates into nodules or non-nodules [14].

III. Results

In this section, we present some results to demonstrate the performance of proposed CAD system which includes the

[image: image3.png]

Fig 3 CAD system using soft tissue technique

soft tissue technique. First, we create the soft tissue technique for the proposed CAD system. Next, the sensitivity for nodule candidate detection on soft tissue image with different rib contrast was plotted to find the peak value of nodule candidate.

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A. MTANN Training

Four x rays and their corresponding bone images in a training set were used to train the MTANN. It is one of the advantages that it needs four training images. In the four images, one was a normal image and the other three contained with nodule image.

In a sub region, the size of the MTANN was 9 x 9 pixels. It was sufficient to cover the width of rib in the image. Three layered MTANN were used to suppress rib where the number of input, hidden and output units were 81, 20 and 1 respectively. Fig 4 shows the bone image and the soft tissue

image with different rib contrast processed by MTANN


B. Nodule Candidate Detection

In fig 4, the sensitivity was highest when the rib contrast

parameter mc was set 0.4. The most nodules were obvious in the nodule candidate detection step. In this plotted graph”,

84 candidates that had max code values in the nodule likelihood map were selected as the origin point to indicate

the performance of the nodule candidate detection

C. Performance of the existing CAD system using soft tissue image

Soft tissue image was applied to replace the x-ray image in existing CAD system. The nodule candidates were detected from the soft tissue image by the use of two stage nodule enhancement method. Fig 5 illustrates the performance improvement of nodule candidate detection step by the use

of soft tissue image. The non-subtle nodule overlapping ribs and clavicles missed in soft tissue image but detected in x-ray image. So, the performance of existing CADs system using x ray image has been improved to a minimum. Then, 30 features were extracted from the soft tissue image after the segmentation of nodule candidate.

[image: image4.png]

Fig 4. Effect of the change in rib contrast on the sensitvity of the proposed CAD system

[image: image5.png]

(a) (b)

Fig 5(a) Nodule candidate detection results based on x ray image (b) Nodule candidate detection results based on soft

tissue image

[image: image6.png]

Fig 6 Sensitivity vs Number of FPs per image

Table I: Features Extracted for Proposed CAD system based on the soft tissue and x ray image


Feature Extraction




Co-ordinates of a nodule candidate



Co-ordinates of a nodule candidate



Co-ordinates of a nodule likelihood values



Calculated by using gray level values



Co-ordinates of a nodule likelihood values



Calculated by using gray level values



Area of a segmented nodule candidate



short and long axes of an ellipse fitted to the nodule candidate



Area of a convex hull of the candidate



distance between the centroid of the candidate and the centroid of the fitted ellipse



μregion – μsurround



σregion- σsurround









Calculated using Gray1



Calculated using Gray2



Calculated using Gray3



Calculated using Gray4




= Gr = (1/8) ∑ Grh


Grh = [1/Nh ] ∑ cos αmn

mn є regionh

t1 ≤ Mmn ≤ t2

where Nh is the number of pixels in the segmented nodule region h




= σ = √ ∑ (Grh- Gr )2




= Gr / σ









λmin λmax



∑ [C(i”,j)2]




∑(i-j)2C(i”,j) ij

Where C(i”,j) ( Co-occurrence

matrix calculated over neighboring pixels and a summation range from the minimum to the maximum pixel value in the pre-processed image



Calculated based on Texture1 and Texture2



Calculated based on Texture1 and Texture2



Calculated based on Texture1 and Texture2



Calculated based on Texture1 and Texture2


False Positive

Lregion / Loverlap

Table II Performance comparison of several existing CAD

system which used the JSRT database

Sensitivity FPs/image Database

Wei et al. 80% 5.4 All

(123/154) (1333/247) nodule and


image in


Coppini et al. 60% 4.3 All nodule

(93/154) (662/154) image in


Schilham et al. 67% 4 All nodule

(103/154) (616/154) image in


Hardie 63% 2 Nodule

(88/140) (280/140) image in


Chen 71% 2 Nodule

(100/140) (466/233) and Normal

image in


Soft tissue 87% 1.5 All nodule

based CAD (134/154) (371/247) and system normal

image in


IV. Conclusion

In a proposed CAD system, a soft tissue technique is a technique used to suppress ribs and clavicles with the help of massive training artificial neural network. Detection of nodule candidate on soft tissue image misclassified as non-nodules due to the suppression of nodule feature. So, it is being developed with sensitivity value calculated as 94%=145/154 by incorporating soft tissue technique after the segmentation of lung. The number of FPs per image was reduced to 1.5 by reducing the values of sensitivity to 87% in proposed CAD system.

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The authors have declared that there is no conflict of interest.


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